To prevent locally generated spam, you need to make sure that everyone using your server knows that sending unsolicited advertisements from your server is not allowed. I have to admit that the idea of such a thing is alien to me. The government agencies and large businesses that I work with would fire anyone who misused corporate property in any way, let alone anyone running a private advertising firm on a corporate server!
But your situation may be different. You may be offering a community service on your system. In that case, you need a written Acceptable Use Policy (AUP) that tells people what type of use is allowed and what isn't. If you're not sure what an aUp should look like, ask your ISP, or check a national ISP. All large ISPs have some form of AUP.
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