Kernel tuning is a difficult subject to handle properly. A default SUSE Linux Enterprise Server kernel works with parameters that do well in most situations. Of the many options that are available for tuning, some are specific for a certain kind of application. If, for example, you want to install Oracle 10g on your server, the Oracle documentation comes with an entire section on kernel-tuning options that you can use. Although these may greatly enhance the performance for your Oracle server, they may decrease the performance for other services you are using. Therefore, even when applying generic parameters, I recommend testing extensively before applying kernel-tuning options to your server.
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